A brief history of TOR.
Identifieur interne : 001361 ( Main/Exploration ); précédent : 001360; suivant : 001362A brief history of TOR.
Auteurs : Robbie Loewith [Suisse]Source :
- Biochemical Society transactions [ 1470-8752 ] ; 2011.
Descripteurs français
- KwdFr :
- Acides aminés (biosynthèse), Animaux (MeSH), Biologie moléculaire (histoire), Biologie moléculaire (tendances), Facteurs de transcription (génétique), Facteurs de transcription (physiologie), Histoire du 20ème siècle (MeSH), Humains (MeSH), Protein-Serine-Threonine Kinases (génétique), Protein-Serine-Threonine Kinases (isolement et purification), Protein-Serine-Threonine Kinases (physiologie), Protéines de Saccharomyces cerevisiae (génétique), Protéines de Saccharomyces cerevisiae (isolement et purification), Protéines de Saccharomyces cerevisiae (physiologie), Saccharomyces cerevisiae (composition chimique), Saccharomyces cerevisiae (génétique), Sirolimus (métabolisme), Sirolimus (pharmacologie).
- MESH :
- biosynthèse : Acides aminés.
- composition chimique : Saccharomyces cerevisiae.
- génétique : Facteurs de transcription, Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae.
- histoire : Biologie moléculaire.
- isolement et purification : Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae.
- métabolisme : Sirolimus.
- pharmacologie : Sirolimus.
- physiologie : Facteurs de transcription, Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae.
- tendances : Biologie moléculaire.
- Animaux, Histoire du 20ème siècle, Humains.
English descriptors
- KwdEn :
- Amino Acids (biosynthesis), Animals (MeSH), History, 20th Century (MeSH), Humans (MeSH), Molecular Biology (history), Molecular Biology (trends), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (isolation & purification), Protein-Serine-Threonine Kinases (physiology), Saccharomyces cerevisiae (chemistry), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (isolation & purification), Saccharomyces cerevisiae Proteins (physiology), Sirolimus (metabolism), Sirolimus (pharmacology), Transcription Factors (genetics), Transcription Factors (physiology).
- MESH :
- chemical , biosynthesis : Amino Acids.
- chemical , genetics : Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemistry : Saccharomyces cerevisiae.
- genetics : Saccharomyces cerevisiae.
- history : Molecular Biology.
- chemical , isolation & purification : Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins.
- chemical , metabolism : Sirolimus.
- chemical , pharmacology : Sirolimus.
- chemical , physiology : Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Transcription Factors.
- trends : Molecular Biology.
- Animals, History, 20th Century, Humans.
Abstract
The TOR (target of rapamycin) serine/threonine kinases are fascinating in that they influence many different aspects of eukaryote physiology including processes often dysregulated in disease. Beginning with the initial characterization of rapamycin as an antifungal agent, studies with yeast have contributed greatly to our understanding of the molecular pathways in which TORs operate. Recently, building on advances in quantitative MS, the rapamycin-dependent phosphoproteome in the budding yeast Saccharomyces cerevisiae was elucidated. These studies emphasize the central importance of TOR and highlight its many previously unrecognized functions. One of these, the regulation of intermediary metabolism, is discussed.
DOI: 10.1042/BST0390437
PubMed: 21428915
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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